AZD2927

Ligand id: 7704

Name: AZD2927

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 43.78
Molecular weight 308.19
XLogP 2.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-fluoro-N-[(2S)-1-(3-hydroxyazetidin-1-yl)-3-methylbutan-2-yl]-N,3-dimethylbenzamide
Synonyms
AZD 2927 | AZD-2927
Comments
AZD2927 blocks the potassium channels Kir3.1/Kir3.4 which convey an inwardly rectifying potassium current (IKACh). AZD2927 was used as an investigative compound as a potential treatment for patients with atrial flutter, but efficacy was not shown. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.
Database Links
GtoPdb PubChem SID 223366037
PubChem CID 57345449
Search Google for chemical match using the InChIKey GAHPWXLXWUVMIV-MRXNPFEDSA-N
Search Google for chemicals with the same backbone GAHPWXLXWUVMIV
Search UniChem for chemical match using the InChIKey GAHPWXLXWUVMIV-MRXNPFEDSA-N
Search UniChem for chemicals with the same backbone GAHPWXLXWUVMIV