AZD3463

Ligand id: 7706

Name: AZD3463

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.09
Molecular weight 448.18
XLogP 3.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
Synonyms
AZD-3463 | CS-1382 | HY-15609 | KB-154896
Comments
AZD3463 was investigated as a treatement for non-small cell lung cancer (NSCLC) patients who have developed resistance to crizotinib. AZD3463 inhibits the tyrosine kinases ALK and IGF1R. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
Database Links
CAS Registry No. 1356962-20-3
GtoPdb PubChem SID 223366039
PubChem CID 56599293
Search Google for chemical match using the InChIKey GCYIGMXOIWJGBU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GCYIGMXOIWJGBU
Search UniChem for chemical match using the InChIKey GCYIGMXOIWJGBU-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GCYIGMXOIWJGBU