GDC-0152

Ligand id: 7733

Name: GDC-0152

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 144.56
Molecular weight 498.24
XLogP 4.41
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide
Synonyms
GDC 0152 | GDC0152
Database Links
CAS Registry No. 873652-48-3
ChEMBL Ligand CHEMBL2063869
PubChem CID 46940575
Search Google for chemical match using the InChIKey WZRFLSDVFPIXOV-LRQRDZAKSA-N
Search Google for chemicals with the same backbone WZRFLSDVFPIXOV
Search UniChem for chemical match using the InChIKey WZRFLSDVFPIXOV-LRQRDZAKSA-N
Search UniChem for chemicals with the same backbone WZRFLSDVFPIXOV
Comments
GDC-0152 is reported to be a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins [1]. The compound is a Smac mimetic, and antagonises binding of caspases to BIR domains of IAP proteins. This action restores apoptosis.