PF-3084014

Ligand id: 7746

Name: PF-3084014

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 12
Topological polar surface area 70.98
Molecular weight 489.33
XLogP 5.36
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide
Synonyms
PF-03084014 | Z-3181
Database Links
CAS Registry No. 865773-15-5
ChEMBL Ligand CHEMBL1770916
PubChem CID 46224413
Search Google for chemical match using the InChIKey VFCRKLWBYMDAED-REWPJTCUSA-N
Search Google for chemicals with the same backbone VFCRKLWBYMDAED
Search UniChem for chemical match using the InChIKey VFCRKLWBYMDAED-REWPJTCUSA-N
Search UniChem for chemicals with the same backbone VFCRKLWBYMDAED
Comments
PF-3084014 is compound 14f in [1] where it is described as a centrally active γ-secretase inhibitor. PF-3084014 also acts as an inhibitor of the NOTCH signalling pathway, and can promote cell cycle arrest and induce apoptosis in leukemia cells [3]. As such, it may additionally enable improved efficacy of the standard chemotherapy used in chronic lymphocytic leukemia (CLL) treatment [2].