florbetaben

Ligand id: 7769

Name: florbetaben    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 39.72
Molecular weight 359.19
XLogP 5.7
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: EMA & FDA (2014))
IUPAC Name
4-[(E)-2-[4-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-N-methylaniline
International Nonproprietary Names
INN number INN
9184 florbetaben (18F)
Synonyms
Names References
[18F]BAY 94-9172 1
AV-1 2
BAY 94-9172 2
Neuraceq®
Database Links
CAS Registry No. 902143-01-5 (source: Scifinder)
PubChem CID 11501341
Search Google for chemical match using the InChIKey NCWZOASIUQVOFA-FWZJPQCDSA-N
Search Google for chemicals with the same backbone NCWZOASIUQVOFA
Search PubMed clinical trials florbetaben
Search PubMed titles florbetaben
Search PubMed titles/abstracts florbetaben
Wikipedia Florbetaben_(18F)
Comments
Florbetaben F18 is the third PET (positron-emission tomography) reagent approved to identify amyloid-β (Aβ) as a diagnostic biomarker in the brains of patients with Alzheimer's disease (AD) [1]. Flutemetamol and florbetapir are the two other PET reagents approved for Aβ detection. These diagnostic tools allow direct and non-invasive in vivo visualisation and quantification of Aβ.