florbetaben

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Ligands
florbetaben

Ligand id: 7769

Name: florbetaben

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	12
Topological polar surface area	39.72
Molecular weight	359.19
XLogP	5.7
No. Lipinski's rules broken	2

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: EMA & FDA (2014))

IUPAC Name
4-[(E)-2-[4-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-N-methylaniline

IUPAC Name

4-[(E)-2-[4-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-N-methylaniline

International Nonproprietary Names
INN number	INN
9184	florbetaben (18F)

Synonyms
Names	References
[¹⁸F]BAY 94-9172	1
AV-1	2
BAY 94-9172	2
Neuraceq®

Database Links
CAS Registry No.	902143-01-5 (source: Scifinder)
PubChem CID	11501341
Search Google for chemical match using the InChIKey	NCWZOASIUQVOFA-FWZJPQCDSA-N
Search Google for chemicals with the same backbone	NCWZOASIUQVOFA
Search PubMed clinical trials	florbetaben
Search PubMed titles	florbetaben
Search PubMed titles/abstracts	florbetaben
Wikipedia	Florbetaben_(18F)

Comments
Florbetaben F18 is the third PET (positron-emission tomography) reagent approved to identify amyloid-β (Aβ) as a diagnostic biomarker in the brains of patients with Alzheimer's disease (AD) [1]. Flutemetamol and florbetapir are the two other PET reagents approved for Aβ detection. These diagnostic tools allow direct and non-invasive in vivo visualisation and quantification of Aβ.

Comments

Florbetaben F18 is the third PET (positron-emission tomography) reagent approved to identify amyloid-β (Aβ) as a diagnostic biomarker in the brains of patients with Alzheimer's disease (AD) [1]. Flutemetamol and florbetapir are the two other PET reagents approved for Aβ detection. These diagnostic tools allow direct and non-invasive in vivo visualisation and quantification of Aβ.