picropodophyllin

Ligand id: 7873

Name: picropodophyllin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 92.68
Molecular weight 414.13
XLogP 1.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(5R,5aR,8aS,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
Synonyms
AXL1717 | podofilox
Database Links
CAS Registry No. 477-47-4
ChEMBL Ligand CHEMBL283120
DrugBank Ligand DB01179
PubChem CID 72435
Search Google for chemical match using the InChIKey YJGVMLPVUAXIQN-HAEOHBJNSA-N
Search Google for chemicals with the same backbone YJGVMLPVUAXIQN
Search UniChem for chemical match using the InChIKey YJGVMLPVUAXIQN-HAEOHBJNSA-N
Search UniChem for chemicals with the same backbone YJGVMLPVUAXIQN
Comments
Picropodophyllin is a lignan extract from podophyllin resin produced in the roots of podophyllum plants. It is an epimer of picropodophyllotoxin. Picropodophyllin has been suggested to act as a selective inhibitor of the insulin-like growth factor 1 receptor (IGF1R) and has potential antineoplastic activity [1-2]. Its effect via IGF1R have been questioned [3].