7-hydroxystaurosporine

Ligand id: 7907

Name: 7-hydroxystaurosporine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 89.68
Molecular weight 482.2
XLogP 3.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
UCN 01 | UCN-01
Database Links
CAS Registry No. 112953-11-4
ChEMBL Ligand CHEMBL1236539
PubChem CID 72271
RCSB PDB Ligand UCN
Search Google for chemical match using the InChIKey PBCZSGKMGDDXIJ-HQCWYSJUSA-N
Search Google for chemicals with the same backbone PBCZSGKMGDDXIJ
Search UniChem for chemical match using the InChIKey PBCZSGKMGDDXIJ-HQCWYSJUSA-N
Search UniChem for chemicals with the same backbone PBCZSGKMGDDXIJ
SynPHARM 80784 (in complex with 3-phosphoinositide dependent protein kinase 1)
Comments
7-hydroxystaurosporine is a cell-permeable staurosporine derivative, with anticancer activity [6]. It reversibly and ATP-competitively inhibits multiple protein kinases, including PKCα, β, γ, δ and ε [5], Chk1 [1-3], Cdc25C-associated protein kinase 1 (cTAK1) [1], Cdk1 [2], PAK4, Cdk5/p25, Chk2 [1], PDK1 [4], Lck [2], p38 MAPK kinase 2 (MAPK14) [3], Akt, GSK-3β [2] and PKA [6].