KX2-391

Ligand id: 7957

Name: KX2-391

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 63.69
Molecular weight 431.22
XLogP 4.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-N-(phenylmethyl)acetamide
Synonyms
KX 2-391 | KX-01 | KX-2-391
Database Links
CAS Registry No. 897016-82-9
ChEMBL Ligand CHEMBL571546
PubChem CID 23635314
Search Google for chemical match using the InChIKey HUNGUWOZPQBXGX-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HUNGUWOZPQBXGX
Search UniChem for chemical match using the InChIKey HUNGUWOZPQBXGX-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone HUNGUWOZPQBXGX
Comments
KX2-391 is an orally bioavailable small molecule Src kinase inhibitor [6] with potential antineoplastic activity. The compound is also suggested to inhibit tubulin polymerization.
Synthesis of KX2-391 is described in US patent US20060160800 [2], where it is compound 134.