AKN-028

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Ligands
AKN-028

Ligand id: 7969

Name: AKN-028

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	6
Hydrogen bond donors	3
Rotatable bonds	3
Topological polar surface area	92.51
Molecular weight	302.13
XLogP	2.06
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Summary
Biological activity
Clinical data
References
Structure

Classification
Compound class	Synthetic organic

IUPAC Name
3-N-(1H-indol-5-yl)-5-pyridin-4-ylpyrazine-2,3-diamine

IUPAC Name

3-N-(1H-indol-5-yl)-5-pyridin-4-ylpyrazine-2,3-diamine

Synonyms
AKN 028
AKN028

Synonyms

AKN 028

AKN028

Database Links
CAS Registry No.	1175017-90-9
PubChem CID	44177328
Search Google for chemical match using the InChIKey	JLRIJKVMMZEKDF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	JLRIJKVMMZEKDF

Comments
AKN-028 is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity [1-2]. The compound inhibits wild-type and mutant FLT3 and KIT kinases.

Comments

AKN-028 is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity [1-2]. The compound inhibits wild-type and mutant FLT3 and KIT kinases.