OSU-03012

Ligand id: 8005

Name: OSU-03012

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 72.94
Molecular weight 460.15
XLogP 8.9
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide
Synonyms
AR-12 | OSU03012
Database Links
CAS Registry No. 742112-33-0
ChEMBL Ligand CHEMBL1650595
PubChem CID 10027278
Search Google for chemical match using the InChIKey YULUCECVQOCQFQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YULUCECVQOCQFQ
Search UniChem for chemical match using the InChIKey YULUCECVQOCQFQ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone YULUCECVQOCQFQ
Wikipedia OSU-03012
Comments
OSU-03012 is a potent inhibitor of recombinant 3-phosphoinositide dependent protein kinase 1 (PDK1). Its discovery is described in [3], where it is compound 34. The PDK1/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumour angiogenesis and represents a promising target for oncology therapeutics [1-2].