GSK2334470

Ligand id: 8008

Name: GSK2334470

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 124.85
Molecular weight 462.29
XLogP 3.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide
Synonyms
GSK 2334470 | GSK-2334470
Database Links
CAS Registry No. 1227911-45-6
ChEMBL Ligand CHEMBL1765740
PubChem CID 46215815
Search Google for chemical match using the InChIKey QLPHOXTXAKOFMU-WBVHZDCISA-N
Search Google for chemicals with the same backbone QLPHOXTXAKOFMU
Search UniChem for chemical match using the InChIKey QLPHOXTXAKOFMU-WBVHZDCISA-N
Search UniChem for chemicals with the same backbone QLPHOXTXAKOFMU
Comments
GSK2334470 is a novel 3-phosphoinositide dependent protein kinase 1 (PDK1) inhibitor. Its discovery is described in [2], where it is compound 28d.
The PDK1/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumour angiogenesis and represents a promising target for oncology therapeutics [1,3].