PHT-427

Ligand id: 8009

Name: PHT-427

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 14
Topological polar surface area 108.57
Molecular weight 409.19
XLogP 8.36
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Synonyms
PHT 427 | PHT427
Database Links
CAS Registry No. 1191951-57-1
ChEMBL Ligand CHEMBL595583
PubChem CID 44240850
Search Google for chemical match using the InChIKey BYWWNRBKPCPJMG-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BYWWNRBKPCPJMG
Search UniChem for chemical match using the InChIKey BYWWNRBKPCPJMG-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone BYWWNRBKPCPJMG
Comments
PHT-427 is a novel dual inhibitor of 3-phosphoinositide dependent protein kinase 1 (PDK1) and Akt (protein kinase B) [3]. The original identification of PHT-427 (compound 14) as an Akt inhibitor is described in [1] where it is shown to bind to the pleckstrin homology (PH) domain of Akt, not to the catalytic ATP binding site. PDK1 activates Akt by phosphorylating Thr308 in Akt's kinase domain.
The PDK1/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumour angiogenesis and represents a promising target for oncology therapeutics [2,4].