tipifarnib

Ligand id: 8025

Name: tipifarnib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 64.15
Molecular weight 488.12
XLogP 5.68
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
International Nonproprietary Names
INN number INN
8066 tipifarnib
Synonyms
R-115777 | R115777
Database Links
CAS Registry No. 192185-72-1
ChEMBL Ligand CHEMBL289228
PubChem CID 159324
RCSB PDB Ligand JAN
Search Google for chemical match using the InChIKey PLHJCIYEEKOWNM-HHHXNRCGSA-N
Search Google for chemicals with the same backbone PLHJCIYEEKOWNM
Search PubMed clinical trials tipifarnib
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Search UniChem for chemical match using the InChIKey PLHJCIYEEKOWNM-HHHXNRCGSA-N
Search UniChem for chemicals with the same backbone PLHJCIYEEKOWNM
SynPHARM 81018 (in complex with farnesyltransferase, CAAX box, beta)
Wikipedia Tipifarnib
Comments
Tipifarnib is a non-peptidomimetic competitive farnesyltransferase inhibitor (FTI) [4].