WZ4003

Ligand id: 8047

Name: WZ4003

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 91.85
Molecular weight 496.2
XLogP 3.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide
Synonyms
WZ-4003
Database Links
CAS Registry No. 1214265-58-3
PubChem CID 72200024
Search Google for chemical match using the InChIKey SDGJBAUIGHSMRI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SDGJBAUIGHSMRI
Search UniChem for chemical match using the InChIKey SDGJBAUIGHSMRI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone SDGJBAUIGHSMRI
Comments
WZ4003 is a selective inhibitor of the AMP-activated protein kinases, NUAK1 and NUAK2 [1].
N.B. compare to HTH-01-015 which is selective for NUAK1. HTH-01-015 and WZ4003 can be used as chemical probes to delineate the biological roles of the NUAK kinases.