GNF-5837

Ligand id: 8071

Name: GNF-5837

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 5
Rotatable bonds 8
Topological polar surface area 98.05
Molecular weight 535.16
XLogP 6.77
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea
Synonyms
GNF 5837 | GNF5837
Database Links
CAS Registry No. 1033769-28-6
ChEMBL Ligand CHEMBL2037226
PubChem CID 59397065
Search Google for chemical match using the InChIKey YYDUWLSETXNJJT-MTJSOVHGSA-N
Search Google for chemicals with the same backbone YYDUWLSETXNJJT
Search UniChem for chemical match using the InChIKey YYDUWLSETXNJJT-MTJSOVHGSA-N
Search UniChem for chemicals with the same backbone YYDUWLSETXNJJT
Comments
GNF-5837 is an investigational, selective, and orally bioavailable inhibitor of the neurotrophic receptor tyrosine kinases TrkA, TrkB and TrkC [1]. This compound is a useful tool for the investigation of TRK biology in human diseases.