GW5074

Ligand id: 8072

Name: GW5074

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 49.33
Molecular weight 518.8
XLogP 4.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
Synonyms
GW-5074 | Raf1 kinase inhibitor I
Database Links
CAS Registry No. 220904-83-6
ChEMBL Ligand CHEMBL72365
PubChem CID 5924208
Search Google for chemical match using the InChIKey LMXYVLFTZRPNRV-KMKOMSMNSA-N
Search Google for chemicals with the same backbone LMXYVLFTZRPNRV
Search UniChem for chemical match using the InChIKey LMXYVLFTZRPNRV-KMKOMSMNSA-N
Search UniChem for chemicals with the same backbone LMXYVLFTZRPNRV
Comments
GW5074 is a potent and selective inhibitor of Raf-1 proto-oncogene, serine/threonine kinase RAF1 (aka c-Raf) in vitro [1].