GNE-7915

Ligand id: 8073

Name: GNE-7915

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 88.61
Molecular weight 443.16
XLogP 2.34
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone
Synonyms
GNE 7915 | GNE7915
Database Links
BindingDB Ligand 50398668
CAS Registry No. 1351761-44-8
ChEMBL Ligand CHEMBL2178134
PubChem CID 58539171
Search Google for chemical match using the InChIKey XCFLWTZSJYBCPF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XCFLWTZSJYBCPF
Search UniChem for chemical match using the InChIKey XCFLWTZSJYBCPF-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone XCFLWTZSJYBCPF
Comments
GNE-7915 is a highly potent, selective, and brain-penetrating inhibitor of leucine-rich repeat kinase 2 (LRRK2) [2].