LY2874455

Ligand id: 8104

Name: LY2874455

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 88.85
Molecular weight 443.09
XLogP 3.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[4-[(E)-2-[5-[(1R)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Synonyms
LY-2874455
Database Links
CAS Registry No. 1254473-64-7
PubChem CID 46944259
RCSB PDB Ligand 6LF
Search Google for chemical match using the InChIKey GKJCVYLDJWTWQU-CXLRFSCWSA-N
Search Google for chemicals with the same backbone GKJCVYLDJWTWQU
Search UniChem for chemical match using the InChIKey GKJCVYLDJWTWQU-CXLRFSCWSA-N
Search UniChem for chemicals with the same backbone GKJCVYLDJWTWQU
Comments
LY2874455 is a potent ATP-competitive inhibitor of FGF receptors and VEGFR2 [1].