glasdegib

Ligand id: 8201

Name: glasdegib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 96.84
Molecular weight 374.19
XLogP 3.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea
International Nonproprietary Names
INN number INN
9930 glasdegib
Synonyms
PF 04449913 | PF-04449913
Database Links
CAS Registry No. 1095173-27-5
ChEMBL Ligand CHEMBL2043437
PubChem CID 25166913
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Comments
Glasdegib is a potent and orally active inhibitor of the hedgehog signalling pathway, acting as an antagonist of the class frizzled GPCR, smoothened (SMO) [1].