UNC1999

Ligand id: 8237

Name: UNC1999

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 95.39
Molecular weight 569.35
XLogP 5.46
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-1-(propan-2-yl)-6-{6-[4-(propan-2-yl)piperazin-1-yl]pyridin-3-yl}-1H-indazole-4-carboxamide
Synonyms
UNC 1999 | UNC-1999
Database Links
CAS Registry No. 1431612-23-5 (source: Scifinder)
PubChem CID 72551585
Search Google for chemical match using the InChIKey DPJNKUOXBZSZAI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DPJNKUOXBZSZAI
Search UniChem for chemical match using the InChIKey DPJNKUOXBZSZAI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DPJNKUOXBZSZAI
Comments
UNC1999 is a cell-permeable chemical probe for histone H3-lysine 27 (H3K27) methyltransferase EZH2 activity, developed by the Structural Genomics Consortium (SGC) in collaboration with the Center for Integrative Chemical Biology and Drug Discovery (CICBDD) at the University of North Carolina [1-2].
Click here to link to the SGC's full list of epigenetics probes.