GSK343

Ligand id: 8240

Name: GSK343

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 95.39
Molecular weight 541.32
XLogP 4.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-(propan-2-yl)-1H-indazole-4-carboxamide
Synonyms
compound 6 [PMID 24900432] [2] | GSK 343
Database Links
CAS Registry No. 1346704-33-3
ChEMBL Ligand CHEMBL2204995
PubChem CID 71268957
Search Google for chemical match using the InChIKey ULNXAWLQFZMIHX-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ULNXAWLQFZMIHX
Search UniChem for chemical match using the InChIKey ULNXAWLQFZMIHX-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ULNXAWLQFZMIHX
Comments
GSK343 is a cell-permeable inhibitor of EZH2 histone H3 methyltransferase activity, developed by GlaxoSmithKline and included in the Structural Genomics Consortium's (SGCs) portfilio of epigenetic probe compounds [1-2].
Click here to link to the SGC's full list of epigenetics probes.