labetuzumab

Ligand id: 8251

Name: labetuzumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
8127 labetuzumab
Synonyms
CEACIDE®
hMN14
Database Links
Specialist databases
IMGT/mAb-DB 62
Other databases
Search PubMed clinical trials labetuzumab
Search PubMed titles labetuzumab
Search PubMed titles/abstracts labetuzumab
Wikipedia Labetuzumab
Comments
Labetuzumab is a humanised mouse monoclonal antibody targeting CEACAM5 (CD66e), a tumour marker that can be measured in serum.
Labetuzumab can be labelled with radioactive isotopes such as yttrium-90 and iodine-131, providing targeted radioimmumotherapy.
Labetuzumab has been used to generate an antibody-drug conjugate (ADC) called labetuzumab govitecan, in which the antibody is covalently bound to SN-38, the active metabolite of the topoisomerase inhibitor, irinotecan.