veltuzumab

Ligand id: 8268

Name: veltuzumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
8932 veltuzumab
Synonyms
hA20
IMMU-106
Database Links
Specialist databases
IMGT/mAb-DB 21
Other databases
Search PubMed clinical trials veltuzumab
Search PubMed titles veltuzumab
Search PubMed titles/abstracts veltuzumab
Wikipedia Veltuzumab
Comments
Veltuzumab is a humanized monoclonal antibody targeting CD20. With the exeption of Asp101 in the complementarity-determining region 3 (CDR3) of the antibody's variable heavy chain, its CDRs are identical to rituximab [2]. This single amino acid substitution appears to account for veltuzumab's reduced off-rate compared to rituximab [2] as well as its enhanced capacity to induce antibody-dependent cellular cytotoxicity (ADCC), and complement-mediated cytotoxicity.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB link.