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Synonyms: AGN-150998 | MP0112
Compound class:
Peptide or derivative
Comment: Abicipar pegol is a VEGFA targeting protein conjugate generated using DARPin® technology [1,3]. The INN record for this construct describes it as a 'pegylated composite protein for clinical applications (CPCA)'. The amino acid sequence for the protein component is provided here. Structurally, the conjugate contains glycyl-seryl-ankyrin repeats (3-35, 36-68, 69-101, 102-123) with a short linker (127-134) and a cysteine di-sulphide bond (1-135), conjugated via a maleimide group linker (thioether bond to C135) to a single linear methoxy polyethylene glycol 20 (mPEG20). DARPins are protein therapeutics that are being developed as an alternative to antigen receptors (antibodies).
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Classification  |
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| Compound class | Peptide or derivative |
| International Nonproprietary Names |
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| INN number | INN |
| 9627 | abicipar pegol |
| Synonyms |
| AGN-150998 | MP0112 |
| Database Links |
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| Specialist databases | |
| IMGT/mAb-DB | 477 |
Reactome Drug
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R-ALL-9679474 |
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Reactome Reaction
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R-HSA-9679477 |
| Other databases | |
| GtoPdb PubChem SID | 252166583 |
| Search PubMed clinical trials | abicipar pegol |
| Search PubMed titles | abicipar pegol |
| Search PubMed titles/abstracts | abicipar pegol |
