abicipar pegol

Home
Ligands
abicipar pegol

Ligand id: 8371

Name: abicipar pegol

Summary
Biological activity
Clinical data
References
Structure

Classification
Compound class	Peptide or derivative

International Nonproprietary Names
INN number	INN
9627	abicipar pegol

Synonyms
AGN-150998
MP0112

Synonyms

AGN-150998

MP0112

Database Links
Specialist databases
IMGT/mAb-DB	477
Other databases
Search PubMed clinical trials	abicipar pegol
Search PubMed titles	abicipar pegol
Search PubMed titles/abstracts	abicipar pegol

Comments
Abicipar pegol is a VEGFA targeting protein conjugate generated using DARPin® technology [1,3]. The INN record for this construct describes it as a 'pegylated composite protein for clinical applications (CPCA)'. The amino acid sequence for the protein component is provided here. Structurally, the conjugate contains glycyl-seryl-ankyrin repeats (3-35, 36-68, 69-101, 102-123) with a short linker (127-134) and a cysteine di-sulphide bond (1-135), conjugated via a maleimide group linker (thioether bond to C135) to a single linear methoxy polyethylene glycol 20 (mPEG20).

Comments

Abicipar pegol is a VEGFA targeting protein conjugate generated using DARPin® technology [1,3]. The INN record for this construct describes it as a 'pegylated composite protein for clinical applications (CPCA)'. The amino acid sequence for the protein component is provided here. Structurally, the conjugate contains glycyl-seryl-ankyrin repeats (3-35, 36-68, 69-101, 102-123) with a short linker (127-134) and a cysteine di-sulphide bond (1-135), conjugated via a maleimide group linker (thioether bond to C135) to a single linear methoxy polyethylene glycol 20 (mPEG20).