PF-00489791

Ligand id: 8377

Name: PF-00489791

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 152.61
Molecular weight 476.2
XLogP 1.05
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-(2-ethoxyethyl)-5-(ethyl-methylamino)-7-[(4-methylpyridin-2-yl)amino]-N-methylsulfonylpyrazolo[5,4-e]pyrimidine-3-carboxamide
Synonyms
PF-489,791 | PF-489791
Database Links
CAS Registry No. 853003-48-2
PubChem CID 11465695
Search Google for chemical match using the InChIKey ZUHZNKJIJDAJFD-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZUHZNKJIJDAJFD
Search UniChem for chemical match using the InChIKey ZUHZNKJIJDAJFD-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ZUHZNKJIJDAJFD
Comments
PF-00489791 is a long-acting, selective and competitive inhibitor of phosphodiesterase 5 (gene symbol PDE5A) inhibitor which is reported to reduce systemic blood pressure in patients with hypertension [2].