MB-3

Ligand id: 8393

Name: MB-3

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 80.67
Molecular weight 186.05
XLogP 0.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2S,3S)-4,5-dioxo-2-propyloxolane-3-carboxylic acid
Synonyms
α-methylene-γ-butyrolactone 3
Database Links
PubChem CID 91827357
Search Google for chemical match using the InChIKey AKWJFOMNTDKSRR-WHFBIAKZSA-N
Search Google for chemicals with the same backbone AKWJFOMNTDKSRR
Search UniChem for chemical match using the InChIKey AKWJFOMNTDKSRR-WHFBIAKZSA-N
Search UniChem for chemicals with the same backbone AKWJFOMNTDKSRR
Comments
MB-3 is reported as a cell-permeable small-molecule inhibitor of the histone acetyltransferase enzyme, general control nonderepressible 5 (GCN5, gene symbol KAT2B) [1]. In vitro, MB-3 has been shown to inhibit GCN5-driven acetylation of the chimeric oncoprotein E2A-PBX1 [3]. E2A-PBX1 represents a non-histone target of GCN5 [4].