molidustat

Ligand id: 8456

Name: molidustat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 101.3
Molecular weight 314.12
XLogP -0.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one
International Nonproprietary Names
INN number INN
9655 molidustat
Synonyms
BAY 85-3934 | BAY-853934 | BAY85-3934
Database Links
BindingDB Ligand 118339
CAS Registry No. 1154028-82-6 (source: PubChem)
PubChem CID 59603622
Search Google for chemical match using the InChIKey IJMBOKOTALXLKS-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IJMBOKOTALXLKS
Search PubMed clinical trials molidustat
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Search UniChem for chemical match using the InChIKey IJMBOKOTALXLKS-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone IJMBOKOTALXLKS
Comments
Molidustat is a compound which inhibits hypoxia inducible factor prolyl hydroxylase (HIF-PH) activity. HIF-PH inhibitors are being investigated as novel therapies for anemia, especially anemia caused by chronic kindney disease (CKD). It is hoped that HIF-PH inhibitors will provide a more effective alternative to the use of erythropoetin replacement therapy plus iron supplementation in CKD patients