PF-01247324

Ligand id: 8521

Name: PF-01247324

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 68.01
Molecular weight 328.99
XLogP 2.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-amino-N-methyl-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide
Database Links
CAS Registry No. 875051-72-2 (source: PubChem)
PubChem CID 11659955
Search Google for chemical match using the InChIKey HPIUHDCRVYDAEJ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HPIUHDCRVYDAEJ
Search UniChem for chemical match using the InChIKey HPIUHDCRVYDAEJ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone HPIUHDCRVYDAEJ
Comments
PF-01247324 is a NaV 1.8 blocker that attenuates nociception and sensory neuron excitability [1]. This publication has an F1000 recommendation. There are six active analogues described in WO2006011050 but without quantitative data.