SGC707

Ligand id: 8552

Name: SGC707

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 74.33
Molecular weight 298.14
XLogP 1.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
Comments
SGC707 is a cell permeable, potent and selective chemical probe for protein arginine methyltransferase 3 (PRMT3), which allosterically inhibits enzyme activity [1]. This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection.
Database Links
GtoPdb PubChem SID 252166753
PubChem CID 90642938
RCSB PDB Ligand 3ZG
Search Google for chemical match using the InChIKey DMIDPTCQPIJYFE-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DMIDPTCQPIJYFE
Search UniChem for chemical match using the InChIKey DMIDPTCQPIJYFE-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DMIDPTCQPIJYFE
SynPHARM 82339 (in complex with protein arginine methyltransferase 3)

Product suppliers

Tocris
SGC 707
Cat. No. 5367