SGC707

Ligand id: 8552

Name: SGC707

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 74.33
Molecular weight 298.14
XLogP 1.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea
Database Links
PubChem CID 90642938
RCSB PDB Ligand 3ZG
Search Google for chemical match using the InChIKey DMIDPTCQPIJYFE-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DMIDPTCQPIJYFE
Search UniChem for chemical match using the InChIKey DMIDPTCQPIJYFE-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DMIDPTCQPIJYFE
SynPHARM 82339 (in complex with protein arginine methyltransferase 3)
Comments
SGC707 is a cell permeable, potent and selective chemical probe for protein arginine methyltransferase 3 (PRMT3), which allosterically inhibits enzyme activity [1]. This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection.