LP99

Ligand id: 8572

Name: LP99

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 95.17
Molecular weight 515.16
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide
Synonyms
compound 60 [PMID: 25864491]
Comments
LP99 is a selective inhibitor of the bromodomain-containing proteins BRD7 and BRD9 [1], proteins which participate in chromatin remodelling as part of the SWI/SNF complex. LP99 is a novel and useful chemical probe for investigating BRD7/9 function. This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection.
Database Links
GtoPdb PubChem SID 252166773
PubChem CID 91827372
RCSB PDB Ligand 6B2
Search Google for chemical match using the InChIKey LVDRREOUMKACNJ-BKMJKUGQSA-N
Search Google for chemicals with the same backbone LVDRREOUMKACNJ
Search UniChem for chemical match using the InChIKey LVDRREOUMKACNJ-BKMJKUGQSA-N
Search UniChem for chemicals with the same backbone LVDRREOUMKACNJ
SynPHARM 82362 (in complex with bromodomain containing 9)