Synonyms: GSK 484 | GSK-484
Compound class:
Synthetic organic
Comment: GSK484 binds to peptidyl arginine deiminase, type IV (PADI4; Q9UM07) and inhibits its activity [1]. PADI4 contributes to regulating the histone code by effecting the citrullination/deimination of histones. PADI4 has strong associations with cancer and immune and inflammatory processes. GSK484 will be a useful tool to enhance understanding of the normal and pathological functions of PADI4.
This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection, developed in collaboration with GlaxoSmithKline (GSK). |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
[(3S,4R)-3-amino-4-hydroxypiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylbenzimidazol-5-yl]methanone |
Synonyms |
GSK 484 | GSK-484 |
Database Links | |
GtoPdb PubChem SID | 252166778 |
PubChem CID | 86340175 |
Search Google for chemical match using the InChIKey | BDYDINKSILYBOL-WMZHIEFXSA-N |
Search Google for chemicals with the same backbone | BDYDINKSILYBOL |
UniChem Compound Search for chemical match using the InChIKey | BDYDINKSILYBOL-WMZHIEFXSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | BDYDINKSILYBOL-WMZHIEFXSA-N |