trifluridine

Ligand id: 8697

Name: trifluridine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 99.1
Molecular weight 296.06
XLogP -0.07
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (Japan only)
IUPAC Name
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione
International Nonproprietary Names
INN number INN
4146 trifluridine
Synonyms
TFT | trifluorothymidine
Comments
Trifluridine was originally approved by the US FDA in 1980, and was used for its antiviral effects (marketed as Vitroptic®). The drug is now being investigated for its antineoplastic (cytotoxic) effect.
Database Links
ChEMBL Ligand CHEMBL1129
DrugBank Ligand DB00432
GtoPdb PubChem SID 252166897
PubChem CID 6256
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