TM-38837

Ligand id: 8705

Name: TM-38837

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 78.4
Molecular weight 616.11
XLogP 9.51
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-(2,4-dichlorophenyl)-4-ethyl-N-piperidin-1-yl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]thiophen-2-yl]pyrazole-3-carboxamide
Synonyms
compound 8 [1]
Database Links
PubChem CID 49779607
Search Google for chemical match using the InChIKey VQOCBFYUDSBDCZ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VQOCBFYUDSBDCZ
Search UniChem for chemical match using the InChIKey VQOCBFYUDSBDCZ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone VQOCBFYUDSBDCZ
Comments
TM-38837 is a cannabinoid CB1 receptor selective inverse agonist/antagonist [1]. This compound has been designed to be peripherally restricted so as to avoid the severe CNS side effects (depression, anxiety and stress disorders) which lead to the withdrawl of rimonabant, the first CB1 receptor antagonist to receive marketing approval. TM-38837 has been investigated as a treatment for obesity and metabolic disorders.