omecamtiv mecarbil

Ligand id: 8740

Name: omecamtiv mecarbil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 86.8
Molecular weight 401.19
XLogP 2.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate
International Nonproprietary Names
INN number INN
9088 omecamtiv mecarbil
Synonyms
AMG 423 | AMG-423 | CK-1827452
Database Links
CAS Registry No. 873697-71-3 (source: PubChem)
ChEMBL Ligand CHEMBL1800955
PubChem CID 11689883
RCSB PDB Ligand 2OW
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Comments
Omecamtiv mecarbil is an investigational small molecule which is a direct activator of cardiac myosin [3]. This compound is being investigated as a novel therapy for patients with chronic heart failure due to systolic dysfunction. Results from the first-in-man study are reported by Teerlink et al. (2011) [4].
Omecamtiv mecarbil is claimed in patent US7507735 B2 [2].