Synonyms: AMG 423 | AMG-423 | CK-1827452
Compound class:
Synthetic organic
Comment: Omecamtiv mecarbil is an investigational small molecule which is a direct activator of cardiac myosin [3]. This compound is being investigated as a novel therapy for patients with chronic heart failure due to systolic dysfunction. Results from the first-in-man study are reported by Teerlink et al. (2011) [4].
Omecamtiv mecarbil is claimed in patent US7507735 B2 [2]. |
|
Classification | |
Compound class | Synthetic organic |
IUPAC Name |
methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate |
International Nonproprietary Names | |
INN number | INN |
9088 | omecamtiv mecarbil |
Synonyms |
AMG 423 | AMG-423 | CK-1827452 |
Database Links | |
CAS Registry No. | 873697-71-3 (source: PubChem) |
ChEMBL Ligand | CHEMBL1800955 |
GtoPdb PubChem SID | 252827398 |
PubChem CID | 11689883 |
RCSB PDB Ligand | 2OW |
Search Google for chemical match using the InChIKey | RFUBTTPMWSKEIW-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | RFUBTTPMWSKEIW |
Search PubMed clinical trials | omecamtiv mecarbil |
Search PubMed titles | omecamtiv mecarbil |
Search PubMed titles/abstracts | omecamtiv mecarbil |
UniChem Compound Search for chemical match using the InChIKey | RFUBTTPMWSKEIW-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RFUBTTPMWSKEIW-UHFFFAOYSA-N |