L-NNA

Ligand id: 8759

Name: L-NNA

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View more information in the IUPHAR Pharmacology Education Project: l-nna

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 7
Topological polar surface area 156.87
Molecular weight 219.1
XLogP -2.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
compound 2 [PMID: 9667974] | nitroarginine
Database Links
CAS Registry No. 2149-70-4
ChEMBL Ligand CHEMBL227744
PubChem CID 440005
RCSB PDB Ligand NRG
Search Google for chemical match using the InChIKey MRAUNPAHJZDYCK-BYPYZUCNSA-N
Search Google for chemicals with the same backbone MRAUNPAHJZDYCK
Search UniChem for chemical match using the InChIKey MRAUNPAHJZDYCK-BYPYZUCNSA-N
Search UniChem for chemicals with the same backbone MRAUNPAHJZDYCK
Wikipedia Nitroarginine
Comments
L-NNA is an arginine analogue used as a biochemical tool in the study of nitric oxide and its biological effects. L-NNA inhibits the endothelial and neuronal isoforms of nitric oxide synthase (NOS), eNOS and nNOS respectively more potently than the inducible iNOS [1].
Selective nNOS inhibitors are being pursued for their potential to treat neurological disorders caused by excessive production of nitric oxide.