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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamide |
Database Links ![]() |
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GtoPdb PubChem SID | 252827519 |
PubChem CID | 72710839 |
RCSB PDB Ligand | 40M |
Search Google for chemical match using the InChIKey | TXEBNKKOLVBTFK-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | TXEBNKKOLVBTFK |
Search UniChem for chemical match using the InChIKey | TXEBNKKOLVBTFK-UHFFFAOYSA-N |
Search UniChem for chemicals with the same backbone | TXEBNKKOLVBTFK |
SynPHARM | 82936 (in complex with fibroblast growth factor receptor 4) |
Comments |
BLU9931 is a selective and irreversible (covalent) inhibitor of the receptor tyrosine kinase, fibroblast growth factor receptor 4 (FGFR4) [1]. The compound is being investigated for its anti-tumour action in hepatocellular carcinomas (HCC) where the fibroblast growth factor 19 (FGF19)/FGFR4 signaling pathway is activated by genetic alteration. |