TP-0903

Ligand id: 8863

Name: TP-0903

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 102.08
Molecular weight 515.19
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide
Synonyms
compound 13 [1] | TP 0903 | TP0903
Database Links
CAS Registry No. 1341200-45-0
ChEMBL Ligand CHEMBL2022968
PubChem CID 56839178
Search Google for chemical match using the InChIKey YUAALFPUEOYPNX-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YUAALFPUEOYPNX
Search UniChem for chemical match using the InChIKey YUAALFPUEOYPNX-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone YUAALFPUEOYPNX
Comments
TP-0903 is an experimental inhibitor of the TAM family receptor tyrosine kinase AXL and is being investigated for its antineoplastic activity [1-2], in particular against pancreatic cancer.