FRAX486

Ligand id: 8938

Name: FRAX486

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 73.39
Molecular weight 512.13
XLogP 4.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-(2,4-dichlorophenyl)-8-ethyl-2-(3-fluoro-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one
Database Links
CAS Registry No. 1232030-35-1 (source: PubChem)
PubChem CID 68060125
Search Google for chemical match using the InChIKey DHKFOIHIUYFSOF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DHKFOIHIUYFSOF
Search UniChem for chemical match using the InChIKey DHKFOIHIUYFSOF-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DHKFOIHIUYFSOF
Comments
FRAX486 is a brain penetrant and orally bioavailable inhibitor of group 1 p21 protein (Cdc42/Rac)-activated kinases (PAK1, PAK2 and PAK3; PAKA subfamily) [1]. Experimental evidence suggests inhibition of PAKs may offer neuroprotective [1-2] and anti-cancer potential.