JNJ-46281222

Ligand id: 8947

Name: JNJ-46281222

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 33.43
Molecular weight 414.2
XLogP 8.13
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-(cyclopropylmethyl)-7-[(4-phenylpiperidin-1-yl)methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Database Links
PubChem CID 49822115
Search Google for chemical match using the InChIKey LYDKDODJIBQNLK-UHFFFAOYSA-N
Search Google for chemicals with the same backbone LYDKDODJIBQNLK
Search UniChem for chemical match using the InChIKey LYDKDODJIBQNLK-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone LYDKDODJIBQNLK
Comments
JNJ-40411813 is a selective and potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor 2 (mGlu2) [1]. PAM binding shows a preference for a G protein bound state of the receptor.