AZD5069

Ligand id: 8948

Name: AZD5069

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 158.56
Molecular weight 476.1
XLogP 1.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[(2R,3S)-3,4-dihydroxybutan-2-yl]oxypyrimidin-4-yl]azetidine-1-sulfonamide
Comments
AZD5069 is a novel, selective antagonist of the chemokine receptor, CXCR2. The structure shown here was drawn from that in [3], which specifies stereochemistry. This structure is identical to Example 47 in patent US7838675 [1]. PubChem records the structure with no specified stereochemistry (CID 59558839).
Small-molecule antagonists of CXCR2 are being developed for their potential to treat inflammatory conditions.
Database Links
GtoPdb PubChem SID 310264729
PubChem CID 56645576
Search Google for chemical match using the InChIKey QZECRCLSIGFCIO-RISCZKNCSA-N
Search Google for chemicals with the same backbone QZECRCLSIGFCIO
Search UniChem for chemical match using the InChIKey QZECRCLSIGFCIO-RISCZKNCSA-N
Search UniChem for chemicals with the same backbone QZECRCLSIGFCIO