fasinumab

Ligand id: 8965

Name: fasinumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
9589 fasinumab
Synonyms
REGN475
SAR164877
Database Links
Specialist databases
IMGT/mAb-DB 418
Other databases
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Comments
Fasinumab is an investigational, fully human IgG4κ monoclonal antibody targeting nerve growth factor (NGF).
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record.
BLAST peptide sequence analysis reveals identical matches to peptide sequences submitted with patent US7988967 [4], with the preferred antibody being called REGN475 therein. REGN475 exhibits high specificity for human NGF, does not cross-react with closely related neurotrophin-3 (NT-3) and inhibits binding of NGF to its receptors TrkA (NTRK1) and p75 (NGFR) [4].