HTH-01-015

Ligand id: 8977

Name: HTH-01-015

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 91.21
Molecular weight 468.24
XLogP 3.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
HTH01-015
Database Links
CAS Registry No. 1613724-42-7 (source: PubChem)
PubChem CID 78357766
Search Google for chemical match using the InChIKey CHSDJDLAKKAWCI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone CHSDJDLAKKAWCI
Search UniChem for chemical match using the InChIKey CHSDJDLAKKAWCI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone CHSDJDLAKKAWCI
Comments
HTH-01-015 is a selective inhibitor of the protein kinase, NUAK family SNF1-like kinase 1 (NUAK1) [1].
N.B. compare to WZ4003 which inhibits both NUAK1 and NUAK2. HTH-01-015 and WZ4003 can be used as chemical probes to delineate the biological roles of the NUAK kinases.