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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol |
Synonyms ![]() |
GDC-0919 | NLG 919 | RG6078 |
Database Links ![]() |
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CAS Registry No. | 1402836-58-1 (source: PubChem) |
GtoPdb PubChem SID | 315661104 |
PubChem CID | 66558287 |
Search Google for chemical match using the InChIKey | YTRRAUACYORZLX-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | YTRRAUACYORZLX |
Search UniChem for chemical match using the InChIKey | YTRRAUACYORZLX-UHFFFAOYSA-N |
Search UniChem for chemicals with the same backbone | YTRRAUACYORZLX |
SynPHARM | 83385 (in complex with indoleamine 2,3-dioxygenase 1) |
Comments |
NLG919 is a potent inhibitor of indoleamine-2,3-dioxygenase (IDO1). IOD1 the first and rate-limiting component of the pathway mediating metabolism of tryptophan to kynurenine. Tryptophan depletion enhances the number and function of the Treg (suppressive) arm of the immune system and inhibits the effector T cell (stimulatory) arm. This action of IDO1 facilitates acquired local and peripheral immune tolerance in normal and pathological conditions. IOD1 inhibitors are being developed as novel therapeutics to reverse the immunosuppression associated with cancer. |