difelikefalin

Ligand id: 9044

Name: difelikefalin

Structure and Physico-chemical Properties

2D Structure

Classification
Compound class	Peptide or derivative

IUPAC Name
4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid

IUPAC Name

4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid

International Nonproprietary Names
INN number	INN
10179	difelikefalin

Synonyms
Names	References
CR845
D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid]
FE-202845
SEQ ID NO: 2	3

Database Links
CAS Registry No.	1024828-77-0 (source: WHO INN record)
PubChem CID	24794466
Search Google for chemical match using the InChIKey	FWMNVWWHGCHHJJ-SKKKGAJSSA-N
Search Google for chemicals with the same backbone	FWMNVWWHGCHHJJ
Search PubMed clinical trials	difelikefalin
Search PubMed titles	difelikefalin
Search PubMed titles/abstracts	difelikefalin
Wikipedia	Difelikefalin

Comments
Difelikefalin is a peripherally acting, highly selective peptide agonist of the κ-opioid receptor, being investigated for its analgesic action [2]. This compound is claimed in patent US7402564 B1 [3]. This patent provides extensive results from preclinical testing, assessing the analgesic and anti-pruritic potential of difelikefalin.

Comments

Difelikefalin is a peripherally acting, highly selective peptide agonist of the κ-opioid receptor, being investigated for its analgesic action [2]. This compound is claimed in patent US7402564 B1 [3]. This patent provides extensive results from preclinical testing, assessing the analgesic and anti-pruritic potential of difelikefalin.