difelikefalin

Ligand id: 9044

Name: difelikefalin

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
IUPAC Name
4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
International Nonproprietary Names
INN number INN
10179 difelikefalin
Synonyms
CR845 | D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid] | FE-202845 | SEQ ID NO: 2 [3]
Comments
Difelikefalin is a peripherally acting, highly selective peptide agonist of the κ-opioid receptor, being investigated for its analgesic action [2]. This compound is claimed in patent US7402564 B1 [3]. This patent provides extensive results from preclinical testing, assessing the analgesic and anti-pruritic potential of difelikefalin.
Database Links
CAS Registry No. 1024828-77-0 (source: WHO INN record)
GtoPdb PubChem SID 315661129
PubChem CID 24794466
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Wikipedia Difelikefalin