PF-05190457

Ligand id: 9060

Name: PF-05190457

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 94.87
Molecular weight 512.24
XLogP 3.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-[2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone
Synonyms
PF-5190457
Database Links
BindingDB Ligand 50019926
ChEMBL Ligand CHEMBL3287218
PubChem CID 58438464
Search Google for chemical match using the InChIKey ZIUDADZJCKGWKR-AREMUKBSSA-N
Search Google for chemicals with the same backbone ZIUDADZJCKGWKR
Search UniChem for chemical match using the InChIKey ZIUDADZJCKGWKR-AREMUKBSSA-N
Search UniChem for chemicals with the same backbone ZIUDADZJCKGWKR
Comments
PF-05190457 is a selective, orally bioavailable and competitive antagonist of the ghrelin receptor [1], with potential therapeutic utility for the treatment of obesity and type 2 diabetes [2].