cenderitide

Ligand id: 9066

Name: cenderitide

Classification
Compound class Peptide or derivative
International Nonproprietary Names
INN number INN
9438 cenderitide
Synonyms
CD-NP
Database Links
ChEMBL Ligand CHEMBL2108721
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Comments
Cenderitide is a designed chimeric natriuretic peptide (NP) engineered to co-activate the two known NP receptors, guanylyl cyclase (GC) -A and -B [1]. It comprises the sequence for C-type natriuretic peptide at the N-terminus (residues 1-22) joined to 15 amino acids (23-37) of the C-terminus of Dendroaspis natriuretic peptide (DNP), isolated from the venom of the green Mamba snake Dendroaspis angusticeps. Synthetic DNP has useful renal activity [2]. Cenderitide combines the beneficial vascular and antiproliferative properties of CNP with the potent natriuretic and diuretic hypotensive effects of DNP.