PL265

Ligand id: 9090

Name: PL265

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 4
Rotatable bonds 17
Topological polar surface area 178.14
Molecular weight 562.21
XLogP 6.34
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Is prodrug? Yes
Active form compound 1a [PMID: 25692029]
IUPAC Name
(2S)-2-[[(2S)-2-[[hydroxy-[(1R)-1-(2-methylpropanoyloxymethoxycarbonylamino)ethyl]phosphoryl]methyl]-3-(4-phenylphenyl)propanoyl]amino]propanoic acid
Synonyms
compound 2a [PMID: 25692029]
Database Links
PubChem CID 58277249
Search Google for chemical match using the InChIKey HLACXNCYLIKGES-YCRNBWNJSA-N
Search Google for chemicals with the same backbone HLACXNCYLIKGES
Search UniChem for chemical match using the InChIKey HLACXNCYLIKGES-YCRNBWNJSA-N
Search UniChem for chemicals with the same backbone HLACXNCYLIKGES
Comments
PL265 is a preclinical, long-acting dual ENKephalinase inhibitor (DENKi), with analgesic potential [1]. See also PL37. PL265 has been developed as a novel therapeutic for control of intractable cancer pain. It is 'Example 4' claimed in patent US2014161839 [2].