L779450

Ligand id: 9129

Name: L779450

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 61.8
Molecular weight 347.08
XLogP 5.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol
Synonyms
compound 1 [PMID:18346893] | compound 2 [PMID: 16260133] | L-779,450 | L-779450
Database Links
BindingDB Ligand 26041
CAS Registry No. 303727-31-3 (source: PubChem)
ChEMBL Ligand CHEMBL373011
PubChem CID 9950176
Search Google for chemical match using the InChIKey WXJLXRNWMLWVFB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone WXJLXRNWMLWVFB
Search UniChem for chemical match using the InChIKey WXJLXRNWMLWVFB-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone WXJLXRNWMLWVFB
Comments
L779450 is a potent ATP competitive inhibitor of RAF kinases [1-2], with potential antineoplastic activity.