bihelical apoA-I mimetic peptide 5A

Ligand id: 9183

Name: bihelical apoA-I mimetic peptide 5A

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
Synonyms
5A peptide
Database Links
PubChem CID 121231406
Search Google for chemical match using the InChIKey FOIYDQXBMQZAML-GNGNDROBSA-N
Search Google for chemicals with the same backbone FOIYDQXBMQZAML
UniParc UPI00015B6DAE
Comments
The initial 2008 study looked at the effect of asymmetry in the lipid affinity of amphipathic helices in bihelical apoA-I mimetic peptides. The 5A sequence was able to solubilize phospholipid vesicles and stimulated cholesterol and phospholipid efflux by the ABCA1 transporter with high specificity [3]. A later 2010 study showed that, like apoA-I, the 5A peptide inhibits acute inflammation and oxidative stress in rabbit carotids and human coronary artery endothelial cells. In vitro, the 5A peptide exerts these beneficial effects through interaction with ABCA1 [4]. Data and peptide analogues related to the latter publication also appeared in patent US8148323 [2]. A 2016 study indicates 5A peptide ameliorated murine colitis by preventing intestinal monocyte infiltration and activation, implying potential for IBD treatment [1] (n.b. there are InChIKey missmatch and submission splitting issues with the current PubChem CID 121231406 entry that we hope to resolve).