clazakizumab

Ligand id: 9195

Name: clazakizumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
9599 clazakizumab
Synonyms
ALD-518
ALD518
BMS-945429
Database Links
Specialist databases
IMGT/mAb-DB 414
Other databases
Search PubMed clinical trials clazakizumab
Search PubMed titles clazakizumab
Search PubMed titles/abstracts clazakizumab
Wikipedia Clazakizumab
Comments
Clazakizumab is an investigational, aglycosylated, humanized (from a rabbit parental antibody) monoclonal antibody targeting interleukin-6, with anti-inflammatory potential [2].
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. BLAST peptide sequence analysis reveals identical matches with peptides claimed in patent US8062864 [3]. Results presented in the patent show that the preferred antibodies block interaction of IL-6 with the IL-6 receptor, but no precise binding affinity data is provided.